It shouldn’t be an issue, I mean, they work on real hardware. I have a fairly large collection of hacked cartridges. I seem to remember trying out a megaman rom that I hacked myself when I first started messing with retropie. The same rom works on an actual cartridge in a real nes.
..actually come to think of it, that particular rom was hacked twice. I hacked somebody else’s hack. lol
^^ my other hobby